Validity of Nipple Discharge Cytology for Mass Screening of Breast Cancer.

The impact of malignant nipple discharge cytology (NDc) in surgical management of breast cancer patients

BACKGROUND The role of nipple discharge cytology (NDc) in the surgical management of breast cancer patients is unclear. We aimed: (i) to evaluate the effect of malignant NDc on the surgical approach to the nipple-areola complex, and (ii) to verify the association between malignant NDc and nipple malignancy. METHODS We retrospectively analyzed a case series of 139 patients with NDc who underwe...

nipple discharge: an early warning sign of breast cancer

nipple discharge (nd) can be the earliest presenting symptom of breast cancer. we hereby present two cases of breast cancer with no palpable mass manifesting as isolated nd, which was whitish in color. in both cases, cytology of the discharge revealed highly pleomorphic cells indicating a high grade malignancy. mammography showed diffuse, extensive microcalcifications. simple mastectomy with ax...

Male Breast Cancer Presenting as Nipple Discharge

Male breast cancer (MBC) is a rare disease and constitutes less than 1% of all breast carcinoma cases. Although MBC most often presents with a palpable mass, failure to recognise the significance of other symptoms may lead to a delay in diagnosis. Nipple discharge (ND) is a rare symptom in men, but it may herald an underlying malignancy. We present two cases of (MBC) presenting with ND and emph...

The role of nipple-aspirate fluid cytology in breast-cancer risk screening.

Molecular analysis of nipple fluid for breast cancer screening.

Lack of sensitivity and specificity of image-based breast cancer screening has urged the exploration of alternate screening modalities. Nipple fluid, which contains breast epithelial cells, is produced in small amounts in the breast ducts of nonlactating women and can be collected by noninvasive vacuum aspiration. After administration of nasal oxytocin, nipple aspiration yields sufficient mater...